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SK-II SK-II R.N.A.Power Essence - Product image showing packaging and label for comedogenic ingredient analysis
SK-IISerum

SK-II R.N.A.Power Essence

Moderate Risk(7)
51 ingredients2 flagged

SK-II R.N.A.Power Essence is a premium anti-aging serum designed to enhance skin firmness and target the signs of aging. The formula is anchored by SK-II’s signature ingredient, Galactomyces Ferment Filtrate (PITERA™), a bio-nutrient rich in vitamins and amino acids that mimics the skin's natural moisturizing factors. Supported by Niacinamide and Glycerin, this essence works to improve skin texture, minimize the appearance of pores, and boost radiance. The texture is silky and lightweight, providing a boost of hydration that leaves the skin feeling supple and resilient. While it offers impressive rejuvenating properties, the inclusion of specific emollient esters provides a rich finish that helps lock in moisture, making it a popular choice for those seeking a more youthful, glowing complexion through advanced fermentation technology.

Our Analysis

Our analysis of the SK-II R.N.A.Power Essence indicates a moderate comedogenic risk level, primarily due to the inclusion of Isopropyl Isostearate. This ingredient carries a high comedogenic rating of 5/5; it is a highly penetrating ester that has a tendency to solidify within the hair follicle, potentially leading to breakouts in congestion-prone individuals. Furthermore, the presence of Olive Oil (Rating: 2/5) introduces oleic acid, which can exacerbate fungal acne (Malassezia) for some users. While PITERA™ provides excellent skin-conditioning benefits, these specific fatty components require caution for those with sensitive, acne-prone pores.

Skin Type Recommendations

This product is best suited for dry, mature, and normal skin types that require intensive firming and hydration. It is not recommended for oily or acne-prone skin due to the high comedogenic rating of Isopropyl Isostearate. Those prone to fungal acne should also avoid this formula due to the olive oil content.

Flagged Ingredients

5
isopropyl isostearate

Highly penetrating ester that solidifies within the follicle.

2
olive oil

High Oleic Acid content (similar to sebum); generally safe but can exacerbate fungal acne (Malassezia).

Want Deeper Analysis?

Run our MACR (Multi-Axis Comedogenic Risk) analysis to get a comprehensive 5-axis risk assessment. This AI-powered analysis evaluates ingredients for Plugging Risk, Barrier Damage, Fungal Acne Risk, Oxidation Risk, and real-world User Reports — giving you personalized scores for your skin type.

Full Ingredient List(51 ingredients)

WaterButylene GlycolGlycerinGalactomyces Ferment FiltrateNiacinamidePentylene GlycolPhytosteryl/​Octyldodecyl Lauroyl GlutamateIsopropyl IsostearateDimethiconeSqualaneXylitolVinyl Dimethicone/​Methicone Silsesquioxane CrosspolymerBoron NitridePanthenolPeg-20 Sorbitan CocoateTocopheryl AcetateDimethicone/​Vinyl Dimethicone CrosspolymerPhenoxyethanolBenzyl AlcoholAcrylates/​C10-30 Alkyl Acrylate CrosspolymerDipentaerythrityl Tri-PolyhydroxystearatePeg-11 Methyl Ether DimethiconeAminomethyl PropanolCeratonia Siliqua (Carob) Fruit ExtractLaureth-7MethylparabenPolymethylsilsesquioxaneSodium Peg-7 Olive Oil CarboxylateXanthan GumDisodium EdtaPeg-100 StearatePeg-7 Glyceryl CocoateAcanthopanax Senticosus (Eleuthero) Root ExtractFragranceEthylhexylglycerinHydrolyzed Soy ProteinCynara Scolymus (Artichoke) Leaf ExtractPolyquaternium-7Hydrolyzed Yeast ProteinPalmitoyl Pentapeptide-4Methylsilanol Tri-Peg-8 Glyceryl CocoateMethiconeCi 77891Ci 77492Phytosteryl/Octyldodecyl Lauroyl GlutamateVinyl Dimethicone/Methicone Silsesquioxane CrosspolymerDimethicone/Vinyl Dimethicone CrosspolymerAcrylates/C10-30 Alkyl Acrylate CrosspolymerRead all the geeky details about Glycerin here >>Read all the geeky details about Niacinamide here >>[more]

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Our analysis is powered by AI and backed by extensive research on comedogenic ingredients — but it's not medical advice. For skin concerns, please consult a dermatologist.